Case Report: B Lymphocyte Disorders Under COVID-19 Inflammatory Pressure

Case Report: B Lymphocyte Disorders Under COVID-19 Inflammatory Pressure

Blog Article

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects humans through the angiotensin converting enzyme-2 (ACE-2) receptor expressed on many cells, including lymphocytes.In Covid-19 patients IL-6 is overexpressed, and hyperactivated plasmacytoid lymphocytes are detected in peripheral blood film.We hypothesize that, due to the unpredictable interaction between the new virus and the COND B cell lineage of infected patients, a cascade of out of control events can ensue, capable of determining unexpected pathologic disorders involving such lineage.Here we report two cases of autoimmune hemolytic anemia (AIHA) and two cases of B-cell hematological malignancies developed or reactivated during acute SARS-CoV-2 infection.The temporal relationship of the events may suggest a potential causal relationship between SARS-CoV-2 infection Ladles and the hematopoietic disorders.

We suggest that special attention should be paid to COVID-19 patients with underlining B cell lineage disorders.